1448-Senescent Cancer Cells in Antitumor Immunity
This review article from Springer Nature examines the complex, dual influence of therapy-induced senescent cancer cells (TISCCs) on the tumor microenvironment. While traditional treatments like chemotherapy and radiation often force cancer cells into a non-proliferative state, these senescent cells remain metabolically active and act as bidirectional regulators of the immune system. Initially, TISCCs can boost antitumor immunity by increasing antigen presentation and recruiting innate immune cells through a secretome known as SASP. However, persistent senescence eventually fosters therapeutic…
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