1441-Lactylation Switch in Cancer Resistance
This review identifies protein lactylation as a transformative "metabolic translator" that converts high lactate levels in the tumor microenvironment into stable programs of cancer treatment resistance. The authors explain how this post-translational modification occurs through both enzymatic pathways, involving writers like AARS1/2 and KATs, and non-enzymatic processes driven by glycolytic byproducts. This molecular switch orchestrates intrinsic resistance by enhancing DNA repair and ferroptosis evasion, while simultaneously driving extrinsic resistance through immune suppression and…
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