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How will EARLY-TAVI and NOTION-3 impact TAVI practice?

When should TAVI be performed—and how should coronary disease be managed in these patients?

Liesbeth Rosseel, Davide Capodanno, and Michael Joner explore two key questions shaping the future of TAVI. They highlight findings from the EARLY-TAVI trial, which shows that early intervention in asymptomatic patients with severe aortic stenosis significantly reduces rehospitalisation. Then, they turn to the NOTION-3 trial, comparing PCI vs medical therapy for CAD prior to TAVI—revealing a benefit in reducing MACE, though at the cost of increased bleeding.

The message is clear: earlier may be better…

The skinny

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