Season 3, Episode 2: The Gut Decides Almost Everything

Epigenetics - The Medicine Nobody Told You About · Oct 13, 2026 · 21m

In this episode, I walk into the gut, the single location where most of your immune system lives. I explain the gut barrier as a one-cell-thick wall, and what happens when tight junctions break under stress, inflammation, or dysbiosis. I introduce zonulin and leaky gut not as a buzzword but as measurable biology, and I explain how the bacteria that live in your gut - your microbiome - train the immune system to tolerate the self. I also talk about sIgA, the antibody that sits on every mucous membrane, and why it disappears under stress. The story of the gut is the story of how most autoimmune…