1248-scMORE: Mapping Trait-Relevant eRegulons
This paper introduces scMORE, a novel computational method designed to identify cell-type-specific gene regulatory networks linked to complex diseases. By integrating single-cell multiomics with genome-wide association studies (GWAS), the framework uncovers how genetic variants influence specific transcription factor programs across various cellular contexts. The researchers successfully applied scMORE to 31 immune- and aging-related traits, revealing critical regulatory mechanisms in Parkinson’s disease and psychiatric disorders. Their findings highlight sex-dependent dysregulation in aged…
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