846-scHiCAR: Trimodal Profiling of Gene Regulatory Landscape

Paper Talk · Apr 24, 2026 · 23m

The paper introduces scHiCAR, an innovative multiomics technology that simultaneously maps the transcriptome, epigenome, and 3D genome from individual cells. This method utilizes a plate-based combinatorial barcoding approach to achieve high throughput, allowing for the cost-effective analysis of millions of cells in a single experiment. Unlike previous techniques, scHiCAR excels at capturing long-range cis-regulatory interactions and open chromatin regions with high precision. Researchers successfully applied this tool to complex tissues, including the mouse brain and skeletal muscle, to…