1707-Human iPSC-Derived Heart Valve Assembloids
Researchers have developed an innovative iPSC-derived heart valve assembloid platform that effectively replicates the three-dimensional architecture and cellular composition of human heart valves. By combining cellular fusion techniques with applied mechanical forces and fluidic shear stress, the system successfully induces valve-like structures and promotes extracellular matrix stratification. This experimental model demonstrates that endothelial-to-mesenchymal transition plays a vital role in valve development, mimicking processes observed in native tissues. Furthermore, the platform…
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