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Gums Have Mitochondria Too: Is Oral Blue Light Therapy an Antimicrobial Tool or Tissue Stressor?

Blue light has real antimicrobial potential in the mouth, especially against black-pigmented periodontal bacteria. But most people skip the more important question: what does blue (and violet) light do to your own gum tissue?

This Deep Dive breaks down a study testing primary human gingival keratinocytes (barrier cells) and gingival fibroblasts (repair/remodeling cells) under 457nm blue vs 418nm violet LED exposure across multiple doses. The focus: ROS generation, cell metabolic activity/viability, cytotoxicity markers, and whether effects are truly ROS-driven (confirmed using NAC as a…

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