1327-Islet Transplantation: Tolerance Versus Immune Evasion
The paper explores the distinct scientific paradigms of transplantation tolerance and immune evasion as methods to achieve long-term survival of islet cell grafts without lifelong medication. Transplantation tolerance focuses on modifying the recipient’s immune system through central mechanisms, like creating mixed hematopoietic chimerism in the thymus, or peripheral strategies such as using regulatory T cells and costimulatory blockade. In contrast, immune evasion is a product-centric approach where grafts are genetically engineered to remain invisible to the host's immune defenses. The…
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