040-The Future of Personalized Cancer Vaccines
This paper discusses the significant advancements and future potential of personalized cancer vaccines (PCVs), highlighting their ability to induce long-term, tumor-specific immune responses. It explains how breakthroughs in next-generation sequencing and bioinformatics have enabled the targeting of neoantigens, which are unique to individual tumors. The text reviews early clinical successes of PCVs, often in combination with immune checkpoint inhibitors, in various cancers including melanoma, pancreatic, and renal cell carcinoma, noting their favorable safety profile and potential for…
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