1505-Architect of Apicomplexan Redox&Metabolic Adaptation

Paper Talk · Aug 28, 2026 · 22m

1 source·Aug 16, 2026

Research published in the journal Cell identifies TgPRO as a critical RNA-binding protein that enables the parasite Toxoplasma gondii to survive high-density environments. By conducting genome-wide CRISPR screens, scientists discovered that crowded conditions increase the demand for nicotinamide adenine dinucleotide (NAD+) and specific metabolic adaptations. TgPRO functions as a novel regulator by directly binding and stabilizing transcripts involved in carbon metabolism and iron-sulfur cluster assembly, representing a unique case of convergent evolution. Parasites…