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Overcoming EGFR-TKI resistance: Emerging therapies and biomarker strategies in NSCLC

Module 1: Beyond EGFR: Addressing actionable drug resistance mechanisms

touchCLINICAL PERSPECTIVES for touchONCOLOGY and touchRESPIRATORY

In this module, Professors Jänne and Girard explore the challenges of resistance to EGFR-targeted therapies in non-small cell lung cancer. They discuss how mechanisms such as MET and HER2 amplification drive resistance to first-line osimertinib, review emerging targeted strategies to overcome these barriers, and highlight the importance of biomarker testing and managing treatment side effects when shaping second-line options for patients.

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