666-Epitranscriptomic Screens for m6A Sites in Cancer
This research article introduces a high-throughput epitranscriptomic screening platform designed to identify functional m6A RNA modifications that drive cancer progression. By utilizing a Cas13-directed methyltransferase system, the researchers mapped the functional landscape of these modifications in prostate and lung cancer models, uncovering over 200 sites that regulate cell growth. A primary discovery identifies CHD9 as a critical tumor-suppressive gene whose protein levels are enhanced by m6A deposition at a specific site. Mechanistically, the study reveals that m6A readers YTHDF1 and…
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