100-Unlocking the Blood-Brain Barrier
This article from Nature Medicine detailing a large-scale proteomic study on the balance of proteins between cerebrospinal fluid (CSF) and plasma in relation to cognitive impairment and aging. Researchers used SomaScan proteomics on paired CSF and plasma samples from over 2,100 individuals to analyze CSF-to-plasma protein ratios, offering insight into brain barrier function. The findings reveal that CSF-to-plasma ratios for many proteins, particularly those from peripheral sources, increase with age, suggesting barrier dysfunction or reduced clearance. Additionally, the study identified sex…
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