HR-Positive Metastatic Breast Cancer — An Interview with Dr Seth Wander on Biomarker Assessment and Related Treatment Decision-Making

Research To Practice | Oncology Videos · Apr 16, 2026 · 1h

Featuring an interview with Dr Seth Wander, including the following topics:

Deciding between liquid and tissue biopsy; role of epigenetics in oncogenic events (0:00)

Potential role of thymidine kinase testing in monitoring response to therapy (4:56)

Interpretation of next-generation sequencing testing; use of targeted therapy (10:59)

Phase III lidERA Breast Cancer trial and its implications for the use of giredestrant (14:19)

Interpreting plots from the Guardant360® test; future applications of circulating tumor DNA (19:07)

Toxicity surrounding use of agents targeting the PAM signaling…