1287-Unmasking Lipid Nanoparticle Protein Corona

Paper Talk · Jul 16, 2026 · 20m

This paper explores the complex biological interface of ionizable lipid nanoparticles (LNPs) used in nucleic acid therapies. While traditional hard nanoparticles form a stable protein corona shell, researchers suggest that soft LNPs interact with biological fluids through lipoprotein fusion and selective protein integration. This distinction is critical because extracellular vesicles and other blood-borne contaminants often interfere with the accurate proteomic analysis of LNP surfaces. By refining isolation and imaging strategies, such as using cryo-electron microscopy, scientists aim to…