1627-IL-17A-γδ T Cells in Mycobacterium abscessus Control
This research identifies IL-17A-producing γδ T cells as a critical component of the immune defense against Mycobacterium abscessus, a difficult-to-treat non-tuberculous mycobacterial infection. Using mouse models and single-cell RNA sequencing, the study reveals that these specialized T cells are activated by macrophage-derived IL-1β and IL-23 via TLR2 signaling. Unlike many other mycobacterial responses, this pathway functions independently of interferon-gamma (IFNγ), offering a vital secondary defense when typical immune pathways are compromised by autoantibodies or genetic factors. The…
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