568-Seq-Scope-X: Submicrometer Spatial Multi-omics

Paper Talk · Feb 28, 2026 · 18m

This research manuscript introduces Seq-Scope-X, a novel spatial biology platform that achieves subcellular and nanoscale resolution by integrating sequencing technology with tissue expansion. By embedding biological samples in an expandable hydrogel and enlarging them before molecular capture, the method overcomes the physical resolution limits of traditional next-generation sequencing. The authors demonstrate its versatility by mapping transcriptomic and proteomic data across diverse tissues, including the liver, brain, and spleen. Their findings highlight the ability to distinguish between…