1638-Multiscale Imaging of Proton Pump-Driven Tumor Acidity

Paper Talk · Oct 2, 2026 · 22m

Researchers have developed a pH-responsive ratiometric photoacoustic sensor (PPS) to visualize and quantify the acidity of the tumor microenvironment (TME). This innovative imaging strategy targets ATP6V0C, a critical proton pump subunit found to be overexpressed in hepatocellular carcinoma (HCC) and directly linked to cancer progression. The PPS nanoparticles switch states in acidic conditions, allowing for high-resolution, deep-tissue monitoring of tumor development from early initiation to distant metastasis. Experimental results demonstrate that this method can accurately delineate tumor…