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856-CARE: for Whole Slide Image Analysis

The paper introduces CARE (Cross-modal Adaptive Region Encoder), a novel foundation model designed to improve computational pathology by moving beyond rigid, grid-based image analysis. Unlike traditional models that treat whole-slide images (WSIs) as collections of isolated square patches, CARE utilizes an adaptive region generator to partition tissue into irregular, morphologically meaningful chunks that respect biological boundaries. The model undergoes a two-stage pretraining process, first learning morphological structures through self-supervised methods and then refining those…

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