862-Spatial VDJ: Mapping Lymphocyte Clonal Dynamics
This research article introduces Spatial VDJ, a novel transcriptomics method designed to map the full-length sequences of B cell and T cell receptors directly within human tissue sections. While traditional single-cell technologies identify these immune receptors, they often lose the spatial context necessary to understand how specific lymphocyte clones interact with their environment. By capturing these sequences alongside whole-transcriptome data, the researchers successfully visualized immune dynamics in human tonsil and breast cancer tissues. Their findings demonstrate that B and T cell…
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