PARP Inhibitors for Patients with Hormone-Sensitive and Castration-Resistant Metastatic Prostate Cancer — An Interview with Dr Wassim Abida (Companion Faculty Lecture)

Research To Practice | Oncology Videos · May 16, 2026 · 27m

Featuring a slide presentation and related discussion from Dr Wassim Abida, including the following topics:

Clinical implications of homologous recombination repair gene alterations and biological rationale for the use of PARP inhibitors (0:00)

Key clinical studies leading to FDA approvals of PARP inhibitors as monotherapy (5:01)

Biological rationale for combining PARP inhibitors with androgen receptor pathway inhibitors and key findings from the Phase III PROpel study (11:03)

Key findings from the Phase III MAGNITUDE and TALAPRO-2 studies (15:10)

Summary of efficacy data with PARP…