1096-Ketogenesis-Ferroptosis Axis in Leukemic Stem Cell
This research identifies a self-contained ketogenic pathway that is essential for the survival of leukemic stem cells (LSCs) in acute myeloid leukemia. While ketone production is typically associated with the liver, these malignant cells utilize fatty acid oxidation to generate the ketone body BHB, which acts as a protective shield against cell death. This metabolic process works by epigenetically suppressing the enzyme FADS2, thereby preventing the remodeling of lipids into forms that are susceptible to ferroptosis, a type of iron-dependent oxidative rupture. Crucially, experimental deletion…
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