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The Truth About Prostate Supplements: My A–C Grades on What Really Works · Intellectual Medicine

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  Even if you do everything perfectly, even if you do
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  everything as good as you can, your disease can still progress.
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  Perhaps it will do so not as rapidly.
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  That's less of a comfort as not at all, right?
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  My goal for you is to die with prostate cancer cells buried in
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  my gland. But I also want you to have
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  Peace of Mind knowing that you put forth best efforts with best
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  information, with the best objective of success.
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  A lot of focus in prostate cancer is based upon the type of
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  cancer you know. Is it aggressive or is it
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  indolent? Let's look at the cell type.
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  We spend far too much energy focusing on the disease that has
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  the man and not nearly as much on the man that has the disease.
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  Perhaps it's not so much the cancer type that has the man for
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  the type of man that has the cancer.
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  Are you a passive fatalist? Well, we'll see what happens.
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  I'll just listen to the docs. And it's not wrong to listen to
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  the docs. It's wrong to believe that they
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  are like a burning Bush and everything that they say is
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  absolute. That's not the case.
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  They have wisdom. They have value.
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  But you're driving the train here, folks.
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  I'm going to talk about supplements, about
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  nutraceuticals was a term that was coined in the late 1970's,
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  the idea that we can apply nutritional substances to affect
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  disease outcomes, to support health.
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  It was novel then and it's novel now.
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  Or what does your doctor have to say about it?
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  Well, most conventional doctors will dismiss it.
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  There's no proof. There's no proof that it works.
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  Of course there isn't. It's generic substances.
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  They've been around for hundreds, thousands of years.
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  In some cases. There's not a pharmaceutical
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  company that would be responsible to its shareholders
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  if they decided that they're going to invest, you know, $100
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  million researching alpha lipoic acid.
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  But we know we know that the things you can do, you don't
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  have to sit there and just accept passive recipient status.
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  So I was watching this TV show with Shannon and so Doctor show
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  and in it the patients are flopping around in a bed with
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  some weird symptom waiting for the brilliant doctor to come up
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  with a thunderstruck diagnosis and miraculously cure them.
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  It's great TV. It's not real most of the time.
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  The intensive care unit in hospitals is filled with dying
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  patients with not much life left, with a lot of expensive
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  comfort level hand holding as a trickle toward the final
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  destination. We don't want to be there.
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  I don't want you to be there. You know, if medicine has a cure
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  that doesn't rob you of vitality, we'll consider that.
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  When it comes to prostate cancer, that pathway is not
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  open. So we take it upon ourselves.
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  You're combining the best advice we can acquire.
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  My purpose in developing the protocol that is pederity
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  protocol and ended after myself, why not?
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  If it's terrible that I'm responsible, if it's great, then
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  good for you is to preserve healthy vitality first and
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  foremost and then apply things that have potential to help.
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  Now among those are nutraceuticals.
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  We'll talk about some of them. I'm going to give you my
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  opinion. We'll give them a letter grade.
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  It's an AB or C with regard to evidence of benefit for prostate
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  cancer. Now how do we come up with those
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  grades? It based upon abundance of
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  studies. How many are out there clinical
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  experience, How do other people fare when they're on this?
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  It is not based upon proof of outcome.
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  Those type of studies are not doable folks.
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  So do not interpret or do not misinterpret the lack of proof
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  of benefit of the absence of potential value important
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  separations. So part of my objective is to
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  not have you choke on 82 supplements.
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  There's a lot of promotional proprietary stuff out there on
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  the Internet. I get it.
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  You're looking for prostate cancer treatment and you come up
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  with bazillion protocols. So first, we're looking for a
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  redundancy. How often does it come up in
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  studies? How good is it?
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  There are levels. One of them is theoretical based
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  upon the pharmacologic principles or chronological
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  characteristics of this supplement.
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  We believe that it can help. Then there is in vitro, you
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  know, Petri dish. Let's take a look at this, see
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  if it kills cancer cells. The next step often time is
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  mice. They call them murine studies.
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  Apparently we don't have a big lobby protecting the well-being
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  of mice because after all, we we give them cancer, often human
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  cancer, so that we can see how it works.
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  And the way we see how it works often times is waiting for them
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  to die or euthanizing them to dissect them.
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  I got to be careful. Maybe we'll launch a a mouse
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  lobby. Anyhow, it's to mankind's
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  benefit that we have these studies.
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  The next step, clinical experience, is in vitro
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  evidence. There is animal study evidence.
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  How about humans? Well, in some cases, there are
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  actually some small studies. We'll talk about those.
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  So one of my most strongly recommended supplements is alpha
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  lipoic acid. Alpha lipoic acid is a naturally
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  occurring substance that the body makes.
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  It's made in the mitochondria of your cells.
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  It's critical to your health and vitality.
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  It is a super potent antioxidant.
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  It neutralizes free radicals. This is one of the reasons why
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  it's made in the mitochondria, the process of producing energy,
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  of ATP. Making energy is productive of
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  free radicals. Left unto itself, that would be
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  very damaging to our health. But the body has balance called
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  a redox balance, right? Antioxidants, free radicals,
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  these things are in balance health.
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  Lipoic acid is one of the things the body makes to help balance
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  that. But there's a problem folks.
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  As we get older we make less of it.
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  So I love alpha lipoic acid as an anti aging help support
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  supplement. What about cancer?
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  Fascinating effect that it can have on cancer.
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  It turns out that it can affect the conversion of how energy is
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  utilized. It helps to block an enzyme
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  called pyruvate dehydrogenase kinase.
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  Pyruvate dehydrogenase is what the body uses to properly
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  produce energy, a process called aerobic phosphorylation.
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  So what we normally use, what your cells thrive upon, oxygen
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  turns into ATP through the chemical process in the cell.
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  Oxygen, ATP, energy, life for the cells, all is good.
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  The pyruvate dehydrogenase kinase breaks down some of that
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  pyruvate dehydrogenase, thereby balancing the amount of oxygen
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  energy production. When cancer arises, it can
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  thrive in what's known as an aerobic glycolysis.
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  That's when cancer prefers this form of energy.
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  Normally y'all have perhaps exercise to the point where you
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  feel your muscles burn Lactic acid?
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  That's anaerobic glycolysis. Not enough oxygen.
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  You're working really hard in the gym leads to the burning
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  sensation in the muscle, a normal process.
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  Cancer flips that around. It takes an enriched oxygenated
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  environment, and instead of making ATP through the normal
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  phosphorylation pathway, it makes it by by lactic acid as a
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  byproduct or aerobic glycolysis unique to cancer.
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  That's their preferred energy method.
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  So if we could do something to deprive them of their preferred
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  energy, that would be a good thing.
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  And what the alpha lipoic acid can do is downgrade the pyruvate
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  dehydrogenase kinase so it doesn't destroy the necessary
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  enzyme to propel healthy energy production.
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  So it shifts, it makes the cancer move away from its
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  preferred energy. It doesn't absolutely kill it,
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  but we want to make it hard for cancer cells to thrive, hard for
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  them to reproduce. You don't do this by fasting,
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  people. This is done with alpha lipoic
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  acid dose. I recommend if you're fighting
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  cancer, at least 600 milligrams a day.
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  In some countries, it's used as a prescription agent. 600
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  milligrams three times a day has been utilized to help with
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  diabetic neuropathy. It can help with autoimmune
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  processes, as I mentioned, one of my favorite life extending
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  youth enhancing supplements that I take every day.
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  It also appears to help prevent metastatic spread of cancer,
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  something that's called the mesenchymal, the epithelial
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  mesenchymal transition. It's when cancer cells move out
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  of their, their little location, start to attack things.
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  So alpha lipoic acid. I give that an A folks.
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  This should be part of your armamentarium.
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  How about melatonin? Interesting right?
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  Melatonin is made from the pineal gland in the brain.
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  It gets released at night as we're sleeping.
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  It's known to be a sleep precursor.
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  In some cases it can help improve quality of sleep.
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  It doesn't work really great as a knock you out go to sleep
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  drug. You've got insomnia.
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  It's been my experience. Melatonin is not usually the
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  solution to the problem. However, it's a powerful
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  antioxidant. It also has an effect on the
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  cancer cells. There's something called the
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  matrix metaloproteinase, MNP. Matrix metaloproteinase is think
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  of that as like the glue between the cells kind of keeps them
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  tight and connected for cancer to metastasize.
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  It likes to break down that glue and penetrate cells.
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  So if we could do something that would be supportive of the the
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  matrix metal proteinases, it would potentially create a
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  physical barrier to cancer cells moving forward.
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  This is part of Doctor Linus Pauling's theory on how cancer
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  could be prevented and one of the reasons he advocated vitamin
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  C, because cancer behaves like scurvy where it breaks down
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  tissue. So protecting it is helpful.
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  Melatonin does that. It helps to support the glue
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  between the cells. What dose should you use?
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  Talk about that in a moment. But first, a study.
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  This study was done on people with advanced prostate cancer.
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  They'd already gone on the route of conventional medicine, which
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  I'm recommending you think twice about.
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  Folks think twice. And in the study, the folks on
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  melatonin survived an average of 153 months compared to 64 months
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  on those who didn't take it. That's a pretty big difference
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  for something as benign as melatonin.
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  Hey, if this were a chemotherapeutic drug that made
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  you puke and lose your hair, I wouldn't be signing up for that.
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  But melatonin, yeah, Mark me present the dose variables
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  between 3:00 to 20 milligrams. My approach, I advocate 20
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  milligrams in the evening, tolerable, safe.
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  In the study of no adverse effects, clinically we have not
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  seen adverse effects. Can you take it in the morning?
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  Well maybe it is synchronized with your circadian rhythm, so
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  ideally it's an evening dose that's preferred.
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  Remember though, anything you do to help you fight your prostate
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  cancer to improve prosthetic health has to be consistent and
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  do not over rely on APSA number. If you start supplements and a
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  month later the PSA goes up from 11:50, it doesn't mean they're
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  failing. It means that the PSA went up
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  two separate things. Now I like to see it stay
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  plateaued. But the most important variable,
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  your vitality and how you feel like how things are going.
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  So melatonin, OK, that gets in a as well.
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  Why? It is a global antioxidant.
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  It's extraordinarily safe natural substance.
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  I like natural stuff. Another one from an African bark
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  called pygium bark. Pygium is and one of those
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  ancient remedies has been around for centuries.
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  The bark is utilized to treat an array of maladies, one of the
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  things that supplements have in common.
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  Almost all of them have some degree of anti oxidative value.
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  It's really hard to know exactly what's working when it comes to
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  supplements because they are so varied in their effect.
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  I think because of that is one of the reasons doctors tune out
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  just because it's too complicated.
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  They'd rather give you a pill. But this is worth adding.
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  So what we found in a study, this was a mice, the mouse
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  study, but it supported the in vitro research as well that the
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  significant reduction in prostate cancer incidence that
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  is the onset of prostate cancer went down in the in the mice
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  that had the pie gym bark. It was 35% incidence of prostate
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  cancer and those without it was 65.
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  So there's some evidence of possible benefit.
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  Human studies are really lacking and it does have a high degree
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  of safety. So the pygium, I'm going to give
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  that AB only because it doesn't have as good a quality of
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  evidence as alpha lipoic acid and melatonin.
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  So put those two first if you have extra money and you don't
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  mind swallowing. Another thing, the PIG bark is
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  reasonable consideration. The dose on that is generally
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  between 50 and 100 milligrams. All right, one more, stay awake
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  with me. Come on, we'll come home stretch
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  Now folks, home stretch. Looking at nettle root.
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  Nettle root is a plant substance.
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  Now, this substance has been shown to have pretty good effect
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  on prosthetic hypertrophy. There are studies that show
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  decreased frequency of urination, less waking up at
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  night, less urgency, kind of nice things.
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  And most men, most of you, if you have some prostate cancer in
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  your bland, it's most common to also have prostatic hypertrophy.
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  They're two separate things. They respond to different kinds
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  of treatment, but they live in the same neighborhood and they
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  can't have overlapping symptoms. So although nettle root is a,
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  I'll give it AC when it comes to cancer because there's not
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  strong evidence of its value against prostate cancer, but I'm
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  going to give it an A when it comes to lower urinary tract
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  symptoms. LUTS called Lutz by doctors.
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  Urgency, frequency, the dose range for the nettle root, it
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  can go up to 1000 milligrams, but I advocated about 500,
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  trying to strike a balance between cost benefit and
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  potential value. Now if you use these things,
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  give it a three month cycle and log to yourself.
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  You know how you doing, how frequent is urination?
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  How much are you waking up at night, putting supplements to
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  work, your lifestyle? So remember man, it's just as
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  important the man that has the disease as the disease that has
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  the man. Now, let me reassure you, even
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  if you do everything perfectly, even if you do everything as
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  good as you can, your disease can still progress.
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  Perhaps it will do so not as rapidly.
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  That's less of a comfort as not at all, right?
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  My goal for you, for most men, for myself, is to die with
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  prostate cancer cells buried in my gland.
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  Because we know if you live long enough, you're probably going to
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  get some. But I also want you to have
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  Peace of Mind knowing that you put forth best efforts with best
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  information with the best objective of success.
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  Be confident, stay strong, keep fighting cancer like a man.
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  I'll look forward to talking to you next time.
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  More to come on these supplements.
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  We're going to go through the grading system so that you'll
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  have a full understanding about how you may want to apply them.
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  I'll talk to you next Time, Team.