1581-Long-Read Sequencing of Melanoma Subclonal Evolution
This scientific paper introduces a novel computational framework that utilizes long-read sequencing of single-cell derived sublines to reconstruct the evolutionary history of melanoma. By analyzing 23 sublines from a mouse model, the researchers integrated diverse data types, including single-nucleotide variants, structural variants, and DNA methylation changes, into a unified phylogenetic tree. Their approach revealed that parallel evolution occurs through independent genomic rearrangements that amplify the same driver genes across different lineages. The study also identifies specific…
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