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A molecule proving psychedelic in animals for decades - blocked entirely by nausea
A molecule proving psychedelic in animals for decades - blocked entirely by nausea
A single compound produced the classic head‑twitch and substituted for LSD across decades of rodent studies, yet it never advanced in humans - because the same molecule caused projectile vomiting in primates that rodents cannot report. How did a reproducible psychedelic signal in animals get concealed by a basic anatomical difference, and what does that mean for interpreting decades of serotonin research?
In this episode, we lay out the experimental trail from the compound’s 1966 synthesis through repeated…
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