519-A Single-Cell Map of the Pan-Tumour Vascular Landscape

Paper Talk · Feb 18, 2026 · 17m

This pan-cancer single-cell atlas reveals the heterogeneity of tumour vasculature. Key findings include APLN+ TipSI cells driving angiogenesis and immunosuppression, and distinct lymphatic endothelial cell lineages linked to prognosis. ER stress also triggers proangiogenic matPCs.

References:

Pan, X., Li, X., Dong, L. et al. Tumour vasculature at single-cell resolution. Nature 632, 429–436 (2024). doi.org

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