075-Fibroblast atlas

Paper Talk · Sep 18, 2025 · 18m

This research integrates 249,156 fibroblasts from 73 studies across 10 tissues to construct a comprehensive single-cell atlas of human fibroblasts. The study classifies 18 distinct fibroblast subtypes, including a previously uncharacterized TSPAN8+ chromatin remodeling fibroblast population associated with poor prognosis and specific interactions with endothelial and T cells. It explores the functional heterogeneity, tissue distribution, differentiation trajectories, aging characteristics, and clinical significance of these subtypes. The findings provide a more refined understanding of…