166-Single-Cell Splicing Isoform Atlas of the Human Heart
This article detailis a comprehensive study on the splicing isoform landscape of the adult human heart under both normal conditions and in heart failure. Leveraging long-read single-nucleus RNA sequencing (snNanoRNAseq), the researchers generated an atlas of full-length RNA isoforms across ten major cardiac cell types. Key findings include that isoform heterogeneity is widespread in the heart and acts as a posttranscriptional buffer system; furthermore, they identified differential isoform usage (DIU) events that are specific to cell types and are significantly shifted in heart failure…
The skinny
The skinny isn't ready yet — notes appear once the transcript is processed.