494-Cell Atlas of Human Gonadal Lineage Specification

Paper Talk · Feb 11, 2026 · 15m

This single-cell atlas of 128,000 cells maps human gonad development from 5 to 12 weeks. It identifies coelomic-epithelium-derived progenitors that branch into supporting and steroidogenic lineages. The study also reveals GnRHR signaling's role in testis differentiation.

References:

Lardenois A, Suglia A, Moore C L, et al. Single-cell exploration of gonadal somatic cell lineage specification during human sex determination[J]. Developmental Cell, 2025.

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