1101-Computational Engineering for PET Recycling
This research outlines a multi-stage computational and rational engineering process used to enhance PHL7, a polyester hydrolase, for more effective PET plastic recycling. By utilizing the Rosetta PROSS algorithm and targeted mutagenesis, scientists developed new enzyme variants that exhibit significantly higher thermal stability and catalytic performance than the original wild-type version. These engineered biocatalysts, such as the R4M10 variant, achieved nearly 115-fold higher activity in low-salt conditions and maintained their structural integrity at temperatures exceeding 95 °C…
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