307-Spatial fibroblast niches define Crohn’s fistulae
This paper details a comprehensive molecular analysis of intestinal fistulae, the penetrating lesions characteristic of Crohn’s disease, using advanced single-cell RNA sequencing and spatial transcriptomics (ST) on tissue samples from 92 individuals. The research defined a unique and abundant cell type called Fistula-Associated Fibroblasts (FAS cells), which are central to the persistence of the disease, unlike the related fibroblasts found in non-fistulating ulcers. These FAS cells organize into distinct spatial niches around the lesion, exhibiting powerful signatures associated with wound…
The skinny
The skinny isn't ready yet — notes appear once the transcript is processed.