099-Unpacking Neurodegeneration with Blood Proteomics

Paper Talk · Sep 28, 2025 · 20m

This paper is a comprehensive research article from Nature Medicine detailing a large-scale plasma proteomics analysis of neurodegenerative diseases (NDs), specifically Alzheimer’s disease (AD), Parkinson’s disease (PD), and frontotemporal dementia (FTD). Researchers leveraged data from the Global Neurodegeneration Proteomics Consortium (GNPC) to identify shared and disease-specific protein alterations across over 10,000 plasma samples. The study employed linear regression, pathway enrichment, and network analyses to map the proteomic landscape of these disorders, revealing common disruptions…