253-Rewiring of cortical glucose metabolism fuels GBM growth
The paper details a study investigating the distinct ways glioblastoma (GBM) tumors metabolize glucose compared to healthy brain tissue. Using stable isotope tracing in human patients and mice, the researchers determined that while the cortex uses glucose primarily for physiological functions like the TCA cycle and neurotransmitter synthesis, aggressive GBM redirects glucose-derived carbons to produce nucleotides and NAD/NADH to support proliferation and invasion. Crucially, the study identifies that many gliomas prioritize environmental serine uptake over glucose-driven synthesis, a…
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