404-MISO for Integrated Protein Purification and Cryo-EM
Researchers have developed a novel microfluidic system designed to streamline the process of protein structure determination using cryo-electron microscopy. This technology, known as the MISO instrument, integrates sample purification and grid preparation onto a single chip, significantly reducing the amount of biological material required. By utilizing this workflow, the team successfully mapped the atomic structure of β-galactosidase starting from just a single bacterial colony. The study also demonstrates the system's versatility by resolving the structures of various membrane proteins…
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