1284-Spatial Biomarkers of Chemotherapy Resistance

Paper Talk · Jul 15, 2026 · 16m

This study investigates estrogen receptor-positive (ER+) breast cancer to identify why some patients experience late relapses despite favorable early prognoses. Researchers used spatial transcriptomics and proteomics to analyze how immune cells are organized within the tumor microenvironment, discovering that immune activity in the stroma and epithelia is often decoupled. A key finding reveals that a high density of stromal CD8+ cytotoxic T-cells acts as a negative predictive marker for chemotherapy success in patients with intermediate recurrence scores. The data suggest that these inflamed…