1106-Amygdala-Like Organoids for Modeling Stress Circuitry

Paper Talk · Jun 10, 2026 · 18m

Researchers have developed human amygdala-like telencephalic organoids (hATOs) and amygdala-hypothalamic (hATO-hypoTO) assembloids to study the development and stress response of the human limbic system. These models successfully replicate the cellular diversity and regional complexity of the amygdala, featuring integrated excitatory and inhibitory neural networks. By exposing these organoids to cortisol, the study demonstrates how stress hormones trigger specific signaling pathways and induce oxidative stress. A key discovery involves the upregulation of BCYRN1, a primate-specific noncoding…