1631-Advanced Renal Cell Carcinoma Resistance

Paper Talk · Sep 30, 2026 · 17m

This study presents a comprehensive single-cell transcriptomic atlas of the advanced renal cell carcinoma (aRCC) tumor microenvironment to uncover mechanisms of drug resistance. By analyzing 61 tumor samples, researchers identified a specific SAA–CEACAM1–TIM-3 axis that drives therapeutic failure by fostering an immunosuppressive niche. The findings highlight that SAA+ tumor cells recruit a unique subset of VEGFA+ neutrophils, which express CEACAM1 to impair the cytotoxic function of CD8+ T cells. Preclinical evidence suggests that targeting this axis through SAA inhibition or CEACAM1–TIM-3…