809-CHARM: 4-Omics of Mammalian Gene Regulatory Landscape

Paper Talk · Apr 17, 2026 · 16m

Researchers have developed CHARM, a sophisticated single-cell multi-omics sequencing method that simultaneously captures four distinct layers of cellular information: gene expression, chromatin accessibility, histone modifications, and three-dimensional genome architecture. By applying this tool to mouse embryonic stem cells and brain tissues, the study provides a comprehensive map of how the 3D epigenome dictates cell identity and function. The data reveals how epigenetic marks are restored during the cell cycle and how regulatory elements cluster in physical space to drive transcription…