146-Spatial Determinants of NSCLC Immunotherapy Resistance

Paper Talk · Oct 19, 2025 · 18m

This article from Nature Genetics presents a multi-omic study using single-cell and spatial transcriptomics to understand resistance to immuno-chemotherapy in non-small-cell lung cancer (NSCLC). Researchers analyzed tumor samples from patients before and after treatment to identify cellular and molecular factors associated with poor outcomes. A key finding reveals that collagen type XI alpha 1 chain-positive (COL11A1+) cancer-associated fibroblasts (CAFs) and secreted phosphoprotein 1-positive (SPP1+) macrophages accumulate at tumor boundaries, forming a structure that physically blocks T…