102-Cellular Mapping of Attributes with Position (CMAP)
This article introduces Cellular Mapping of Attributes with Position (CMAP), an innovative computational method designed to enhance the resolution of spatial transcriptomic analysis by accurately mapping individual cells to their precise locations within tissue microenvironments. Traditional methods, while providing valuable data, often compromise on single-cell resolution or gene recovery, particularly for intricate tissues like the cancer immune microenvironment. CMAP utilizes a three-level "divide-and-conquer" strategy—Domain Division, Optimal Spot assignment, and Precise Location…
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