1570-Microbial Synthesis for Cardiometabolic Health
This research identifies a novel biological pathway where gut microbiota utilize dietary nitrate and non-heme iron to produce dinitrosyl iron complexes (DNICs). These bioactive molecules travel from the intestines to peripheral tissues as stable entities, functioning as hormone-like signaling agents that operate independently of free nitric oxide. Experiments reveal that DNICs provide significant cardiometabolic protection by activating the sGC-cGMP pathway and inhibiting leucine uptake, which effectively prevents the overactivation of the mTORC1-SREBP1 signaling axis. Consequently, treatment…
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