Pharma 60: Mycobacterial Disease - Winning a War of Attrition
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This episode explores tuberculosis, non-tuberculous mycobacterial disease (including MAC), and leprosy as the pharmacology of endurance. Mycobacteria grow slowly, hide within host cells, and possess formidable cell walls-forcing therapy to be prolonged, multi-drug, and meticulously coordinated. We examine cell wall synthesis inhibition, RNA polymerase t…
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