1590-Colorectal Cancer Metastasis
This research reveals that colorectal cancer (CRC) cells facilitate metastasis by temporarily adopting a wound-healing program typically used by skin cells. By utilizing patient-derived organoids and serial transplantation in mice, scientists identified a rare population of disseminated tumor cells (DTCs) that shed their intestinal identity to express keratins like KRT17. This transition is driven by a combination of reduced EZH2 activity and activated YAP signaling, allowing cancer clusters to survive during travel to distant organs like the liver. The study demonstrates that this lineage…
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