995-HOTSCRAMBL lncRNA: A Genetic Safeguard for Stem Cells
Researchers have identified a novel long non-coding RNA named HOTSCRAMBL, which plays a vital role in regulating human hematopoietic stem cells (HSCs). A specific inherited genetic variant, rs17437411, disrupts this RNA’s structure and impairs its ability to recruit the splicing factor SRSF2 to the HOXA9 gene. This structural failure leads to inefficient HOXA9 splicing, which reduces the self-renewal capacity of stem cells and promotes their differentiation. While this process results in slightly lower blood counts, it serves as a protective mechanism against blood cancers and clonal…
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