141-CAR-T therapy in solid tumors
This paper provides an extensive review of Chimeric Antigen Receptor (CAR) T cell therapy specifically focusing on its application and challenges in treating solid tumors, contrasting its limited success here with its proven efficacy in hematologic malignancies. It identifies major obstacles, such as antigenic heterogeneity and the immunosuppressive tumor microenvironment (TME), which hinder CAR-T cell performance in solid tumors. The text details various emerging strategies being explored to enhance CAR-T cell function, including genetic engineering to improve T cell persistence and…
The skinny
The skinny isn't ready yet — notes appear once the transcript is processed.