346-Microbial Signals in Primary and Metastatic Brain Tumors
The multi-institutional study investigates the presence and biological significance of microbial elements within primary and metastatic brain tumors (gliomas and brain metastases). Researchers utilized rigorous, orthogonal methods, including fluorescence in situ hybridization (FISH), immunohistochemistry, and spatial molecular imaging (SMI), on 243 tissue samples to validate the presence of intracellular bacterial 16S rRNA and lipopolysaccharides localized to tumor, immune, and stromal cells. Although standard culture methods failed to grow cultivable bacteria, sequencing workflows identified…
The skinny
The skinny isn't ready yet — notes appear once the transcript is processed.