627-Macrophages: Next-Generation Cancer Immunotherapy
This review examines tumor-associated macrophages (TAMs), which are diverse immune cells capable of either driving cancer growth or eliminating malignant cells. While traditional therapies attempted to broadly deplete these cells, modern strategies focus on reprogramming or effectorizing them to restore their natural anti-tumor functions. Scientists are now targeting "don’t-eat-me" signals to enhance phagocytosis and using genetic engineering, such as CAR-M cells, to create precision immune responses. The research also reveals that tumors influence myeloid progenitors systemically in the bone…
The skinny
The skinny isn't ready yet — notes appear once the transcript is processed.