574-OmicVerse: Bridging Bulk and Single-Cell Transcriptomics
The paper introduces OmicVerse, a specialized Python-based platform designed to streamline the analysis of bulk and single-cell RNA-seq data. A central feature of this framework is BulkTrajBlend, an innovative tool that utilizes Generative Adversarial Networks (GANs) to address the problem of missing or "omitted" cell types in single-cell datasets. By integrating information from whole-tissue bulk sequencing, the model can effectively interpolate missing cellular populations and accurately reconstruct developmental trajectories that would otherwise be lost. The research demonstrates the…
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