733-Tumor-restraining Fibroblasts Emerge to Chemotherapy
Recent research has identified a unique subpopulation of cancer-associated fibroblasts (CAFs), known as lipoCAFs, that emerge in bladder cancer patients who respond well to chemotherapy. These specialized cells undergo lipid oxidation reprogramming to produce a signaling molecule called 11-HETE, which effectively boosts the body's immune response against tumors. By inhibiting a specific protein within CD8+ T cells, these fibroblasts enhance the ability of immune cells to attack and destroy cancer. This discovery highlights the functional heterogeneity of the tumor microenvironment…
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